Let's identify where the problem is. Try downloading a different planetarium program and use that instead. Cartes du Ciel is one option for PC, there are others.
Do the motors run in correct/both directions when you have it slew to a location? From one of you comments it appears they do not. I suspect your cables, I had a similar issue but these tests below can help confirm that.
Assuming that you have verified the jumpers on the FYSETC are set correctly (see Kevin's comment):
What is the overall configuration? Do you have a Wifi or network add on? Using the Android App or the web interface can be helpful if either are available.
If you set
#define AXIS1_DRIVER_REVERSE ON
#define AXIS2_DRIVER_REVERSE ON
and then reload the software, does the direction change? If not, then it is probably the cables - hard to point to driver cards if 4 of them are behaving the same.
And remember that movements around the pole can be confusing for a GEM. See question 2 in the FAQ.
You can also send movement commands directly to the OnStep via the USB using the Arduino serial monitor (I think, someone will correct this if I am remembering incorrectly). See the command protocol page of the Wiki.